Antiinfectives

Our group is devoted to identify and develop novel antiinfective drugs by addressing bacterial immune evasion and virulence factors in a pathogen specific manner. Due to the reduced selection pressure, we expect to minimize resistance formation and spreading.
Moreover, we also address the New Delhi metallo-beta Lactamase 1 in order to develop a combinatorial therapy of specific Carbapenems with NDM-1 inhibitors.
Our biochemical screening assays are validated according to the standards of the European Lead Factory and we have identified inhibitors with IC50s in the single digit µM range, which serve as Proof-of-Concept.
We now seek to find new (Pharma) partners interested in antiinfective development.

Novel anttiinfectives

What we offer

Our group is devoted to identify and develop novel antiinfective drugs by addressing bacterial immune evasion and virulence factors in a pathogen specific manner. Due to the reduced selection pressure, we expect to minimize resistance formation and spreading.
Moreover, we also address the New Delhi metallo-beta Lactamase 1 in order to develop a combinatorial therapy of specific Carbapenems with NDM-1 inhibitors. Moreover, we have established screening assays for S. aureus Sortase A.
Our biochemical screening assays are validated according to the standards of the European Lead Factory and we have identified inhibitors with IC50s in the single digit µM range, which serve as Proof-of-Concept.

What we are looking for

We now seek to find new (Pharma) partners interested in antiinfective development. Specifically, we are looking for partners providing us with chemical or natural compound libraries, or support our work with fragment-based screening approaches.

Keywords

  • Pharma
    • [search] Production of drugs
  • Biotech
    • [search] Drug Development

Collaboration sought

  • Research & development
  • Partnership for international development projects

Responsible

Principal Investigator

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